employee
Russian Federation
employee
Russian Federation
Abstract. The conditions of keeping animals and birds are increasingly provoking stressful situations for them. The occurrence of stress helps to reduce the body's resistance and creates conditions for the development of diseases of various etiologies. With a decrease in resistance, the quantity of products and their quality decreases. It is possible to prevent stress in animals and poultry by using adaptogens of various origins. The search for optimal means that meet all the requirements of prevention remains to this day an urgent problem of practical veterinary medicine. The purpose of this study was to give a morphohistochemical assessment of the effect of a feed mineral supplement on the digestive organs during experimental immunosuppression in laboratory animals. In the conditions of experimental immunosuppression, to identify the effect of mineral feed additives on the structure of organ cells and their metabolism. Methods. To confirm the effectiveness of the mineral adaptogen, histological, morphometric and histochemical studies of the digestive organs were performed. As a result of the conducted research on preventive feeding of a feed mineral supplement of domestic production, its immune- and organoprotective role was revealed. The most sensitive organs to the action of adverse factors (lymphoid formations in the intestinal wall) have been identified. Morphometrically and histochemically determined the reliability of morphological changes in them. During prophylactic feeding of a feed mineral supplement of domestic production in the digestive organs, the revealed changes did not have total destruction, approaching the structure and metabolic processes in cells to the structure of these organs in intact animals. Scientific novelty. For the first time, a comparative microstructural, histochemical and morphometric assessment of the digestive organs in the body of laboratory animals under conditions of artificially induced immunosuppression was carried out, confirming the immune- and organoprotective effect of a feed mineral supplement of domestic production, which can be considered as a mineral adaptogen.
stress, immunosuppression, prevention, adaptogen, histology, histochemistry, morphometry, feed additives
1. Loretts O. G., Donnik I. M., Bykova O. A., Neverova O. P., Gumenyuk O. A., Shakirova S. S., Meshcheriakova G. V. Nonspecific resistance of broilers on the background of application of a herbal complex of biologically active compounds under the conditions of industrial technology // Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018. T. 9. No. 6. Pp. 1679-1687.
2. Bespamyatnyh E. N., Krivonogova A. S., Donnik I. M., Isaeva A. G. Podhody k korrekcii immunobiologicheskogo profilya zhivotnyh // Veterinariya Kubani. 2018. № 5. S. 10-13.
3. Donnik I. M., Loretts O. G., Barashkin M. I., Sadovnikov N. V., Shusharin A. D., Elesin A. V., Semenova N. N. Reviewing the influence of copper, lead and zinc accumulation on the morphofunctional liver and kidney state in broiler chickens under experimental toxicosis // Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018. T. 9. No. 6. Pp. 859-873.
4. Krasochko P. A., Holod V. M., Shabunin S. V. [i dr.] Prikladnye aspekty immunomodulyacii s ispol'zovaniem sredstv prirodnogo proishozhdeniya. Krasnodar: Kubanskiy gosudarstvennyy agrarnyy universitet imeni I.T. Trubilina, 2021. 398 s.
5. Shackih E. V. Perevarimost' i ispol'zovanie pitatel'nyh veschestv korma broylerami pri vvedenii v predstartovyy racion razlichnyh form soedineniy yoda // Fundamental'nye i prikladnye aspekty veterinarnoy mediciny na granice vekov: sbornik materialov mezhdunarodnoy konferencii, posvyaschennoy 100-letiyu SibNIVI-VNIIBTZh. Omsk, 2021. S. 376-381.
6. Cecchini S., Rossetti M., Caputo A., Bavoso A. Effect of dietary inclusion of a commercial polyherbal Formulation on some physiological and immune parameters in healthy and stressed hens [e-resource] // Czech Journal of Animal Science. 2019. No. 64. Pp. 448-458. URL: https://www.agriculturejournals.cz/web/cjas.htm?type=article&id=189_2019-CJAS (date of reference: 12.12.2020). DOI:https://doi.org/10.17221/189/2019-CJAS.
7. Lugovyh T. A., Shackih E. V. Sorbcionnye preparaty v kormlenii pticy // Innovacionnye tehnologii v agrarnom proizvodstve: materialy mezhregional'noy nauchno-prakticheskoy konferencii. Ekaterinburg, 2020. S. 82-84.
8. Galiev D. M., Shackih E. V. Vliyanie kormovoy dobavki BSh na myasnuyu produktivnost' cyplyat-broylerov // Proizvodstvo plemennoy produkcii (materiala) po napravleniyam otechestvennogo plemennogo zhivotnovodstva na osnove uskorennoy selekcii: sbornik materialov mezhdunarodnoy nauchno-prakticheskoy konferencii «Strategicheskie zadachi po nauchno-tehnologicheskomu razvitiyu APK». Ekaterinburg, 2018. S. 33-37.
9. Drozd M. N. Effektivnost' mineral'nogo adaptogena v usloviyah eksperimental'noy immunosupressii // Agrarnyy vestnik Urala. 2021. № 12 (215). S. 29-40. DOI:https://doi.org/10.32417/1997-4868-2021-215-12-29-40.
10. Kundryukova U. I., Drozdova L. I. Veterinarno-sanitarnaya i morfologicheskaya ocenka muskulatury bedrennoy i grudnoy grupp myshc cyplyat-broylerov s nizshey kategoriey upitannosti // Nauchnaya zhizn'. 2018. № 12. S. 222-231.
11. Shackih E. V., Galiev D. M. Mineral'nyy sorbent v kombikormah dlya cyplyat-broylerov // Pticevodstvo. 2018. № 11-12. S. 45-49.
12. Caregorodceva A. E., Valamina I. E., Usevich V. M. Morfo-funkcional'nye harakteristiki immunnoy sistemy pri inducirovannoy immunosupressii v eksperimente // Aktual'nye voprosy sovremennoy medicinskoy nauki i zdravoohraneniya: sbornik statey IV Mezhdunarodnoy (74 Vserossiyskoy) nauchno-prakticheskoy konferencii. Ekaterinburg, 2019. S. 1192-1196.
13. Shackih E. V., Nufer A. I., Galiev D. M. Natural'nye al'ternativnye stimulyatory rosta i ih vliyanie na produktivnost' cyplyat-broylerov // Pticevodstvo. 2020. № 1. S. 31-36.
14. Galiev D. M., Shackih E. V. Morfogistologicheskoe sostoyanie pecheni cyplyat-broylerov pri ispol'zovanii kormovoy dobavki BSh [Elektronnyy resurs] // Vestnik biotehnologii. 2019. № 2 (19). URL: http://aon.urgau.ru/uploads/article/pdf_attachment/154 (data obrascheniya: 17.02.2022).
15. Shatskikh E. V., Korolkova-Subbotkina D. E., Galiev D. M. The influence of biologically active additives on the morpho-biochemical parameters of the blood of broiler chickens // Agrarian Bulletin of the Urals. 2021. No. 04 (207). Pp. 93-98. DOI:https://doi.org/10.32417/1997-4868-2021-207-04-93-98.
